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1. Apelqvist J, Armstrong DG, Lavery LA, Boulton AJ. Resource utilization and economic cost of care based on a randomized trial of vacuum-assisted closure therapy in the treatment of diabetic foot wounds. The American Journal of Surgery 2008; 195(6):782-8.

2. Argenta, A., Webb K., Simpson J., Gordon S., Kortesis B., Wanner M., Kremers L., Morykwas M. Deformation of Superficial and Deep Abdominal Tissues with Application of a Controlled Vacuum. European Tissue Repair Society, Focus group meeting Topical Negative Pressure (TNP) Therapy, 4–6 December 2003, London.

3. Augustin M, Zschocke I. Nutzenbewertung der Ambulanten und Stationären V.A.C. Therapie aus Patientensicht: Multicenterstudie mit Patientenrelevanten Endpunkten[Patient evaluation of the benefit of outpatient and inpatient vacuum therapy. Multicenter study with patient-relevant end points]. MMW, Fortschritte der Medizin Originalia 2006; 148(1): 25-32.

4. Bennett G, Dealey C, Posnett J. The cost of pressure ulcers in the UK. Age and Ageing 2004; 33(3): 23.0-5.

5. Blume PA, Walters J, Payne W, Ayala J, Lantis J. Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers. Diabetes Care 2008; 31: 631-6.

6. Bucalo B, Eaglstein WH, Falanga V. Inhibition of cell proliferation by chronic wound fluid. Wound Repair and Regeneration 1993; 1(3):181-6.

7. Cullum N, Nelson EA, Flemming K, Sheldon T. Systematic reviews of wound care management: (5)bed; (6) compressor; (7) laser therapy; therapeutic ultrasound, electrotherapy and elctro magnetic therapy. Health Technology Assessment 2001; 5(9).

8. Field FK, Kerstein MD. Overview of wound healing in a moistenvironment. American Journal of Surgery 1994; 167(1A): 2S-6S.

9. Joseph E, Hamori CA, Bergman S, Roaf E, Swann NF, Gasper WA. A prospective randomized trial of vacuum-assisted closure versus standard therapy of chronic non-healing wounds. Wounds 2000; 12(3): 60–67.

10. Kamolz LP, Andel H, Haslik W, Winter W, Meissl G, Frey M. Use of subatmospheric pressure therapy to prevent burn wound progression in human: first experiences. Burns 2004; 30(3):253-8.

11. McNulty AK, Schmidt M, Feeley T, Kieswetter K. Effects of negative pressure wound therapy on fibroblast viability, chemotactic signaling, and proliferation in a provisional wound (fibrin) matrix. Wound Repair and Regeneration, the international journal of tissue repair and regeneration 2007; 15(6); 838-46.

12. Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Annals of Plastic Surgery 1997; 38(6): 553-62.

13. Morykwas MJ, Faler BJ, Pearce DJ, Argenta LC. Effect of varying levels of subatmospheric pressure on the rate of granulation tissue formation in experimental wounds in swine. Annals of Plastic Surgery 2001; 47(5):547-51.

14. Mouës CM, Bemd GJCM van den, Heule F, Hovius SER. Comparing conventional gauze therapy to vacuum-assisted closure wound therapy: A prospective randomised trial. Journal of Plastic, Reconstructive & Aesthetic Surgery 2007; 60(6): 672-81.

15. Mouës CM, Bemd GJCM van den, Meerding WJ, Hovius SER. An economic evaluation of the use of TNP on full-thickness wounds. Journal of Wound Care 2005; 14(5): 224-7.

16. Orgill DP, Bayer LR, Neuwalder J, Felter RC. Microdeformational wound therapy- a new era in wound healing. Business Briefing, Global Surgery – Future Directions in Surgery 2005; 22-5.

17. Representative microbial in-vitro test data; KCI internal data on file.

18. Saxena VSM, Hwang CW, Huang S, Eichbaum Q, Ingber D, Orgill DP. Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plastic and Reconstructive Surgery 2004; 114(5):1086-96.

19. Timmers MS, Le Cessie S, Banwell P, Jukema GN. The Effects of Varying Degrees of Pressure Delivered by Negative-Pressure Wound Therapy on Skin Perfusion. Annals of Plastic Surgery 2005 ; 55(6):665-71.

20. Vuerstaek JDD, Vainas T, Wuite J, Nelemans P, Neumann MHA, Veraart JCJM. State-of-the-art treatment of chronic leg ulcers: a randomized controlled trial comparing vacuum-assisted closure (V.A.C.) with modern wound dressings. Journal of Vascular Surgery 2006; 44(5):1029-37.

21. Miller PR, Meredith JW, Johnson JC, Chang MC. Prospective evaluation of vacuum-assisted fascial closure after open abdomen: planned ventral hernia rate is substantially reduced. Annals of Surgery 2004 May; 239(5): 608-614. Study conducted using V.A.C.® Therapy System with V.A.C. ® GranuFoam™ dressings.

22. Inman, K.J., et al. Clinical Utility and Cost-Effectiveness of an Air Suspension Bed in the Prevention of Pressure Ulcers. JAMA, March 3, 1993; Vol 269; No 9.

23. Gunther et al. Increased Lymphatic Flow: Effects of a Pulsating Air Suspension Bed System. Wounds 1996;8(4):134-140.

24. Yarbrough et al. Therapeutic and Financial Outcomes Using a Pulsating Low-Air-Loss Surface for Patients surviving severe posterior burns. Ostomy Wound Management 2000;46(3):64-69.

25. L.J Smith and M.H. El Habbal, Application of kinetics in intensive care management, 1996, Intensive Care Med 22:964-967.

26. Raoof et al. Effect of Combined Kinetic Therapy and Percussion Therapy on the Resolution of Atelectasis in Critically Ill Patients. Chest 1999;115:1658-1666.

27. Holody et al. The effect of mechanical Vibration Physiotherapy on Arterial Oxygenation in Acutely Ill Patients with Atelectasis or Pneumonia. Am Rev Respir Dis. 1981 Oct;124(4):372-5.



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